Robo1 Gene Summary [Mouse]
Predicted to enable LRR domain binding activity; axon guidance receptor activity; and identical protein binding activity. Involved in several processes, including circulatory system development; neuron development; and regulation of gene expression. Acts upstream of or within several processes, including axon guidance; heart development; and mammary duct terminal end bud growth. Located in axolemma. Is expressed in several structures, including autopod; central nervous system; genitourinary system; jaw; and sensory organ. Used to study cystic kidney disease and lung cancer. Human ortholog(s) of this gene implicated in autosomal recessive congenital nystagmus; combined or isolated pituitary hormone deficiency 8; congenital nystagmus; multiple myeloma; and plasmacytoma. Orthologous to human ROBO1 (roundabout guidance receptor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Robo1 |
| Official Name | roundabout guidance receptor 1 [Source:MGI Symbol;Acc:MGI:1274781] |
| Ensembl ID | ENSMUSG00000022883 |
| Bio databases IDs | |
| Aliases | roundabout guidance receptor 1 |
| Synonyms | CPHD8, DUTT1, Gm310, H-Robo-1, LOC102551586, LOC683548, NORS, NYS8, roundabout guidance receptor 1, Roundabout homolog 1, Roundabout homolog 1 precursor, SAX3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Robo1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Immunoglobulin V-Type
- immunoglobulin domain
- axon guidance receptor
- ectodomain
- LRR-domain binding
- Immunoglobulin I-set domain
- protein binding
- Fibronectin type 3 domain
- identical protein binding
- cytoplasmic domain
- FN3
- transmembrane domain
- Immunoglobulin like
- intracellular domain
- transmembrane receptor
- Immunoglobulin V-set domain
Pathways
Biological processes and signaling networks where the Robo1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-small cell lung cancer
- lung cancer
- breast cancer
- epithelial cancer
- epithelial neoplasia
- cancer
- liver cancer
- hyperplasia
- schizophrenia
- Alzheimer disease
role in cell
- formation
- activation in
- proliferation
- quantity
- growth
- chemotaxis
- adhesion
- outgrowth
- migration
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cytoskeleton
- Cytoplasm
- cilia
- cell surface
- cell borders
- cellular membrane
- cytosol
- axonal membrane
- growth cone
- perikaryon
- axons
- dendrites
- callosal axon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Robo1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Roundabout signaling pathway
- positive regulation of MAP kinase activity
- positive regulation of Rho protein signal transduction
- chemorepulsion involved in postnatal olfactory bulb interneuron migration
- endocardial cushion formation
- nervous system development
- cell migration involved in sprouting angiogenesis
- cell adhesion
- homophilic cell adhesion
- positive regulation of Notch signaling pathway
- outflow tract septum morphogenesis
- positive regulation of vascular endothelial growth factor signaling pathway
- positive regulation of axonogenesis
- heart induction
- negative regulation of chemokine-mediated signaling pathway
- positive regulation of vascular endothelial growth factor receptor signaling pathway
- axon midline choice point recognition
- activation of cysteine-type endopeptidase activity involved in apoptotic process
- aortic valve morphogenesis
- pulmonary valve morphogenesis
- ventricular septum morphogenesis
- negative regulation of gene expression
- aorta development
- positive regulation of gene expression
- negative regulation of negative chemotaxis
- negative regulation of cell migration
- negative regulation of mammary gland epithelial cell proliferation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- neuron projection
- plasma membrane
- axon
- cell surface
- endoplasmic reticulum-Golgi intermediate compartment membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- LRR domain binding
- axon guidance receptor activity