Gamt Gene Summary [Mouse]
Predicted to enable guanidinoacetate N-methyltransferase activity and identical protein binding activity. Acts upstream of or within several processes, including creatine biosynthetic process; regulation of growth; and spermatogenesis. Predicted to be located in cytosol. Predicted to be active in cytoplasm and nucleus. Is expressed in brain; foregut-midgut junction; future brain; lens; and liver. Used to study guanidinoacetate methyltransferase deficiency. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and guanidinoacetate methyltransferase deficiency. Orthologous to human GAMT (guanidinoacetate N-methyltransferase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gamt |
| Official Name | guanidinoacetate methyltransferase [Source:MGI Symbol;Acc:MGI:1098221] |
| Ensembl ID | ENSMUSG00000020150 |
| Bio databases IDs | |
| Aliases | guanidinoacetate methyltransferase |
| Synonyms | AA571402, CCDS2, GMT, guanidinoacetate methyltransferase, guanidinoacetate N-methyltransferase, HEL-S-20, PIG2, Spintz1, TP53I2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gamt often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- methyltransferase
- guanidinoacetate N-methyltransferase
- enzyme
- protein binding
- AdoMet_MTases
- S-adenosylmethionine-dependent methyltransferase
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- disorder of creatine synthesis
- guanidinoacetate methyltransferase deficiency
- hereditary disorder
- oligozoospermia
role in cell
- expression in
- phosphorylation in
- number
- survival
- density
- maturation
- damage
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gamt gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of multicellular organism growth
- muscle contraction
- spermatogenesis
- creatine metabolic process
- creatine biosynthetic process
- methylation
- organ morphogenesis
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- methyltransferase activity
- guanidinoacetate N-methyltransferase activity