Ckb Gene Summary [Mouse]
Enables creatine kinase activity. Involved in futile creatine cycle. Located in myelin sheath. Is active in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; musculature; and sensory organ. Orthologous to human CKB (creatine kinase B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Ckb |
| Official Name | creatine kinase, brain [Source:MGI Symbol;Acc:MGI:88407] |
| Ensembl ID | ENSMUSG00000001270 |
| Bio databases IDs | |
| Aliases | creatine kinase, brain |
| Synonyms | B-CK, Ck-3, CKBB, Ckbr, CPK-B, creatine kinase B, Creatine kinase b chain, creatine kinase, brain, Creatine kinase b type, Creatinine phosphokinase bb, HEL-211, HEL-S-29, KCRB |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ckb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- ubiquitin protein ligase binding
- Phosphagen (guanidino) kinases
- creatine kinase
- ATP:guanido phosphotransferase, N-terminal domain
- protein binding
- ATP:guanido phosphotransferase, C-terminal catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- epithelial cancer
- prostate cancer
- Huntington disease
- non-insulin-dependent diabetes mellitus
- endometriosis
- prostatic carcinoma
- gastric adenocarcinoma
- gastric epithelial cancer
- organismal death
role in cell
- apoptosis
- phosphorylation in
- cell viability
- migration
- phagocytosis by
- opening
- abnormal morphology
- doxorubicin resistance
- cell spreading
- homeostasis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- Extracellular Space
- Mitochondria
- cytosol
- apical membrane
- anchoring junction
- junctional complexes
- perikaryon
- dendrites
- cell-cell adherens junctions
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ckb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phosphocreatine biosynthetic process
- substantia nigra development
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- mitochondrion
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- ubiquitin protein ligase binding
- creatine kinase activity