Kcnmb1 Gene Summary [Mouse]
Enables calcium-activated potassium channel activity. Predicted to be involved in several processes, including cellular response to bile acid; cellular response to ethanol; and detection of calcium ion. Located in membrane. Part of voltage-gated potassium channel complex. Is expressed in arterial system; sensory organ; skeleton; and tarsus. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human KCNMB1 (potassium calcium-activated channel subfamily M regulatory beta subunit 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kcnmb1 |
| Official Name | potassium large conductance calcium-activated channel, subfamily M, beta member 1 [Source:MGI Symbol;Acc:MGI:1334203] |
| Ensembl ID | ENSMUSG00000020155 |
| Bio databases IDs | |
| Aliases | potassium large conductance calcium-activated channel, subfamily M, beta member 1 |
| Synonyms | BKbeta, BKbeta1, BKCA beta subunit, BKCA β subunit, Bk β, hbeta1, hslo-beta, hslo-β, K(VCA)beta, k(VCA)beta-1, K(VCA)β, k(VCA)β-1, Maxi Potassium Channel beta, Maxi Potassium Channel β, potassium calcium-activated channel subfamily M regulatory beta subunit 1, potassium calcium-activated channel subfamily M regulatory β subunit 1, potassium large conductance calcium-activated channel, subfamily M, beta member 1, potassium large conductance calcium-activated channel, subfamily M, β member 1, SLO-BETA, slo-beta-1, SLO-β, slo-β-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kcnmb1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Calcium-activated potassium channel, beta subunit
- calcium-activated potassium channel
- potassium channel regulator
- protein binding
- ion channel
Pathways
Biological processes and signaling networks where the Kcnmb1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic obstructive pulmonary disease
- atrial fibrillation
- diabetes mellitus
- atrial flutter
- autosomal dominant polycystic kidney disease
- endometrial cancer
- tracheoesophageal fistula
- uterine serous papillary cancer
regulates
- Ca2+
- K+
role in cell
- response by
- conduction
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- perinuclear region
- cellular membrane
- recycling endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kcnmb1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- potassium ion transport
- cellular response to ethanol
- detection of calcium ion
- potassium ion transmembrane transport
- synaptic transmission
- cellular response to hypoxia
- vasodilation
Cellular Component
Where in the cell the gene product is active
- voltage-gated potassium channel complex
- synapse
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- calcium-activated potassium channel activity
- potassium channel regulator activity