Ewsr1 Gene Summary [Mouse]
Predicted to enable RNA binding activity; identical protein binding activity; and transcription coregulator activity. Predicted to be involved in regulation of DNA-templated transcription. Located in nucleus. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; hemolymphoid system gland; and sensory organ. Human ortholog(s) of this gene implicated in Ewing sarcoma. Orthologous to human EWSR1 (EWS RNA binding protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Ewsr1 |
| Official Name | Ewing sarcoma breakpoint region 1 [Source:MGI Symbol;Acc:MGI:99960] |
| Ensembl ID | ENSMUSG00000009079 |
| Bio databases IDs | |
| Aliases | Ewing sarcoma breakpoint region 1 |
| Synonyms | bK984G1.4, Ewing sarcoma breakpoint region 1, Ewing sarcoma homolog, EWS, EWS-FLI1, EWSH, EWS RNA-binding protein 1, LOC100912481 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ewsr1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RGG domain
- RNA recognition motif (RRM) superfamily
- activation domain
- Ser-Tyr-Gln-Gly-rich transactivating domain
- low complexity domain
- RNA recognition motif
- nuclear localization sequence
- transcription activation domain
- protein binding
- identical protein binding
- glutamine serine tyrosine-rich domain
- G/S Y G/S triplet repeat
- RNA binding
- Ewing sarcoma activation domain
- Zn-finger in Ran binding protein and others
- zinc finger domain
- SYGQQS repeat
- RNA-binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- non-small cell lung cancer
- liver cancer
- Ewing sarcoma
- osteosarcomagenesis
- tumorigenesis
- retinoblastoma
- retinoblastoma formation
- breast cancer
role in cell
- production in
- proliferation
- expression in
- apoptosis
- synthesis in
- survival
- binding in
- growth
- differentiation
- methyl methanesulfonate sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- perinuclear region
- nucleoplasm
- nucleoli
- interchromatin granule clusters
- Cajal bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ewsr1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of transcription, DNA-dependent
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- Cajal body
- nucleolus
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- calmodulin binding
- identical protein binding
- transcription cofactor activity
- RNA binding
- protein binding
- metal ion binding