Ppm1m Gene Summary [Mouse]
Enables manganese ion binding activity and phosphoprotein phosphatase activity. Involved in protein dephosphorylation. Located in nucleus. Is expressed in brain; genitourinary system; heart; liver; and respiratory system. Orthologous to human PPM1M (protein phosphatase, Mg2+/Mn2+ dependent 1M). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ppm1m |
| Official Name | protein phosphatase 1M [Source:MGI Symbol;Acc:MGI:1915155] |
| Ensembl ID | ENSMUSG00000020253 |
| Bio databases IDs | |
| Aliases | protein phosphatase 1M |
| Synonyms | 2810423O19Rik, PP2CE, PP2C-eta, protein phosphatase 1M, protein phosphatase, Mg2+/Mn2+ dependent 1M, protein phosphatase, Mg2+/Mn2+ dependent, 1M |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ppm1m often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Protein phosphatase 2C
- protein phosphatase
- phosphatase
- manganese ion binding
- Serine/threonine phosphatases, family 2C, catalytic domain
- PP2Cc
Pathways
Biological processes and signaling networks where the Ppm1m gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ppm1m gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein dephosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- manganese ion binding
- myosin phosphatase activity
- [pyruvate dehydrogenase (lipoamide)] phosphatase activity