Gtf3c5 Gene Summary [Mouse]
Predicted to enable DNA binding activity and RNA polymerase III general transcription initiation factor activity. Predicted to contribute to RNA polymerase III type 1 promoter sequence-specific DNA binding activity and RNA polymerase III type 2 promoter sequence-specific DNA binding activity. Acts upstream of or within skeletal muscle cell differentiation. Predicted to be located in nucleoplasm. Predicted to be part of transcription factor TFIIIC complex. Is expressed in early conceptus; inner cell mass; and oocyte. Orthologous to human GTF3C5 (general transcription factor IIIC subunit 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gtf3c5 |
| Official Name | general transcription factor IIIC, polypeptide 5 [Source:MGI Symbol;Acc:MGI:1917489] |
| Ensembl ID | ENSMUSG00000026816 |
| Bio databases IDs | |
| Aliases | general transcription factor IIIC, polypeptide 5 |
| Synonyms | 2700084A09RIK, general transcription factor IIIC, polypeptide 5, general transcription factor IIIC subunit 5, HLH Transcription Factor 4, TFiiiC2-63, TFIIIC63, TFIIICepsilon |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gtf3c5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase III transcription factor (TF)IIIC subunit HTH domain
- transcription regulator
- Tau95 Triple barrel domain
- protein binding
Pathways
Biological processes and signaling networks where the Gtf3c5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gtf3c5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transcription from RNA polymerase III promoter
- skeletal muscle cell differentiation
- transcription initiation from RNA polymerase III promoter
- 5S class rRNA transcription from RNA polymerase III type 1 promoter
- tRNA transcription from RNA polymerase III promoter
Cellular Component
Where in the cell the gene product is active
- transcription factor TFIIIC complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA polymerase III type 1 promoter sequence-specific DNA binding
- DNA binding
- protein binding
- core RNA polymerase III binding transcription factor activity
- RNA polymerase III type 2 promoter sequence-specific DNA binding