Dpysl3 Gene Summary [Mouse]
This gene encodes a protein that belongs to the TUC (TOAD-64/Ulip/CRMP) family of proteins. Members of this family are phosphoproteins that function in axonal guidance and neuronal differentiation during development and regeneration of the nervous system. A mutation in the human gene is associated with amyotrophic lateral sclerosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]
Details
| Type | Protein Coding |
| Official Symbol | Dpysl3 |
| Official Name | dihydropyrimidinase-like 3 [Source:MGI Symbol;Acc:MGI:1349762] |
| Ensembl ID | ENSMUSG00000024501 |
| Bio databases IDs | |
| Aliases | dihydropyrimidinase-like 3 |
| Synonyms | CRMP-4, dihydropyrimidinase-like 3, DIHYDROPYRIMIDINASE RELATED protein-3, DRP-3, LCRMP, TUC4, ULIP, ULIP-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dpysl3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- dihydroorotase, multifunctional complex type
- phosphoprotein binding
- enzyme
- protein binding
- metallo-dependent_hydrolases
- identical protein binding
- SH3-domain binding
- glycosaminoglycan binding
- allantoinase
- binding protein
- cytoskeletal protein binding
- Amidohydrolase family
- D-hydantoinase
Pathways
Biological processes and signaling networks where the Dpysl3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- metastasis
- diabetic nephropathy
- androgenic alopecia
- idiopathic scoliosis
- daytime sleepiness
- aortic valve calcification
- chronic sinusitis
- pathological denervation
- lung metastasis
role in cell
- expression in
- proliferation
- formation
- formation in
- migration
- cell death
- outgrowth
- quantity
- movement
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- exocytic vesicle
- Extracellular Space
- transition region of growth cone
- Nucleus
- actin filaments
- cytosol
- neuromuscular junctions
- growth cone
- neurites
- synapse
- perikaryon
- axons
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dpysl3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- pyrimidine base catabolic process
- actin crosslink formation
- negative regulation of neuron projection development
- positive regulation of filopodium assembly
- response to axon injury
- positive regulation of neuron projection development
- cellular response to cytokine stimulus
- neuron development
- actin filament bundle assembly
- negative regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- exocytic vesicle
- growth cone
- extracellular space
- cell body
- cytosol
- synapse
- filamentous actin
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- chondroitin sulfate binding
- hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
- identical protein binding
- protein binding
- SH3 domain binding
- dihydropyrimidinase activity
- filamin binding