Aatk Gene Summary [Mouse]
Enables protein tyrosine kinase activity. Acts upstream of or within brain development; neuron apoptotic process; and peptidyl-tyrosine autophosphorylation. Predicted to be located in several cellular components, including dendrite; growth cone; and perinuclear region of cytoplasm. Is expressed in brain; corpus callosum; spinal cord; spinal cord gray matter; and spinal cord white matter. Orthologous to human AATK (apoptosis associated tyrosine kinase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Aatk |
| Official Name | apoptosis-associated tyrosine kinase [Source:MGI Symbol;Acc:MGI:1197518] |
| Ensembl ID | ENSMUSG00000025375 |
| Bio databases IDs | |
| Aliases | apoptosis-associated tyrosine kinase |
| Synonyms | AATYK, AATYK1, apoptosis-associated tyrosine kinase, KIAA0641, LMR1, LMTK1, LOC100292717, LOC688299, mKIAA0641, p35BP, PPP1R77 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Aatk often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein kinase (unclassified specificity)
- Protein Kinases, catalytic domain
- p35 binding domain
- Protein tyrosine and serine/threonine kinase
- tyrosine kinase domain
- protein binding
- Protein kinase domain
- protein-tyrosine kinase
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Aatk gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
- neurotic disorder
- depressive disorder
- neuroticism
- major depression
- metabolic syndrome X
- Alzheimer disease
- infection by vesicular stomatitis virus
regulated by
- 5-hydroxytryptamine
- L-triiodothyronine
- diethylnitrosamine
- metformin
- phenobarbital
- tretinoin
- phosphoenolpyruvate
- troglitazone
- TNF
- 32dcl cells
role in cell
- expression in
- apoptosis
- outgrowth
- abnormal morphology
- outgrowth in
- elongation in
- transport in
- elongation
- stabilization in
- transport
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Plasma Membrane
- growth cone
- recycling endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Aatk gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peptidyl-tyrosine autophosphorylation
- brain development
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein tyrosine kinase activity
- protein binding
- protein serine/threonine kinase activity