Gak Gene Summary [Mouse]
Predicted to enable clathrin binding activity and cyclin binding activity. Acts upstream of or within several processes, including epithelial cell differentiation; establishment of skin barrier; and intrahepatic bile duct development. Predicted to be located in Golgi apparatus and clathrin-coated vesicle. Predicted to be active in cytoplasm; intracellular membrane-bounded organelle; and vesicle. Is expressed in several structures, including central nervous system; liver; and retina. Orthologous to human GAK (cyclin G associated kinase). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gak |
| Official Name | cyclin G associated kinase [Source:MGI Symbol;Acc:MGI:2442153] |
| Ensembl ID | ENSMUSG00000062234 |
| Bio databases IDs | |
| Aliases | cyclin G associated kinase |
| Synonyms | Auxilin 2, Cyclin G Associated Kinase, D130045N16Rik, DNAJ26, DNAJC26 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gak often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- clathrin binding domain
- Protein tyrosine and serine/threonine kinase
- serine/threonine kinase domain
- protein binding
- PTP_DSP_cys
- Protein kinase domain
- cyclin binding
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Protein Kinases, catalytic domain
- C2 domain of PTEN tumour-suppressor protein
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Gak gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- Alzheimer disease
- Parkinson disease
role in cell
- replication in
- proliferation
- growth
- cell viability
- quantity
- differentiation
- development
- organization
- assembly
- endocytosis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- Cytoplasm
- perinuclear region
- focal adhesions
- Plasma Membrane
- vesicles
- Golgi Apparatus
- Endoplasmic Reticulum
- Mitochondria
- cytosol
- trans Golgi network
- nuclear foci
- clathrin-coated vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gak gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein localization in Golgi apparatus
- Golgi organization
- intracellular transport
- chaperone mediated protein folding requiring cofactor
- Golgi to lysosome transport
- endoplasmic reticulum organization
- receptor-mediated endocytosis
- clathrin-mediated endocytosis
- synaptic vesicle uncoating
- clathrin coat assembly
- negative regulation of neuron projection development
- clathrin coat disassembly
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- focal adhesion
- cytoplasm
- intracellular membrane-bounded organelle
- membrane
- cytosol
- vesicle
- Golgi apparatus
- clathrin-coated vesicle
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- chaperone binding
- cyclin binding
- clathrin binding
- protein serine/threonine kinase activity