Fstl3 Gene Summary [Mouse]
Enables activin binding activity. Acts upstream of or within negative regulation of BMP signaling pathway. Located in extracellular space. Is expressed in several structures, including brain; foregut; limb; male reproductive gland or organ; and thymus. Orthologous to human FSTL3 (follistatin like 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fstl3 |
| Official Name | follistatin-like 3 [Source:MGI Symbol;Acc:MGI:1890391] |
| Ensembl ID | ENSMUSG00000020325 |
| Bio databases IDs | |
| Aliases | follistatin-like 3 |
| Synonyms | E030038F23Rik, FLRG, follistatin-like 3, FSRP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fstl3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- activin binding
- protein binding
- KAZAL_FS
- fibronectin binding
- Follistatin/Osteonectin-like EGF domain
- follistatin (FS) domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- hypertension
- Crohn disease
- hyperplasia
- colorectal cancer
- organismal death
- left ventricular systolic dysfunction
- ovarian endometriosis
- endometrioma
- microvesicular hepatic steatosis
role in cell
- apoptosis
- expression in
- phosphorylation in
- differentiation
- growth
- hypertrophy
- number
- quantity
- transdifferentiation
- area
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- Nucleus
- endoplasmic reticulum lumen
- nucleoplasm
- nerve ending
- secretory granules
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fstl3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organismal development
- negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
- positive regulation of cell-cell adhesion
- positive regulation of transcription from RNA polymerase II promoter
- hemopoietic progenitor cell differentiation
- regulation of transcription from RNA polymerase II promoter
- negative regulation of BMP signaling pathway
- ossification
- negative regulation of activin receptor signaling pathway
- negative regulation of osteoclast differentiation
- cell differentiation
- regulation of BMP signaling pathway
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- nucleus
- extracellular space
- extracellular region
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- activin binding
- protein binding
- fibronectin binding