Kdm3a Gene Summary [Mouse]
Enables chromatin binding activity; histone H3K9 demethylase activity; and transcription coregulator activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; positive regulation of transcription by RNA polymerase II; and spermatid nucleus elongation. Located in cytoplasm and male germ cell nucleus. Is expressed in several structures, including cerebral cortex; extraembryonic ectoderm; ovary; and pituitary gland. Used to study obesity. Human ortholog(s) of this gene implicated in cervical cancer and colon cancer. Orthologous to human KDM3A (lysine demethylase 3A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kdm3a |
| Official Name | lysine (K)-specific demethylase 3A [Source:MGI Symbol;Acc:MGI:98847] |
| Ensembl ID | ENSMUSG00000053470 |
| Bio databases IDs | |
| Aliases | lysine (K)-specific demethylase 3A |
| Synonyms | 1700105C21Rik, C230043E16Rik, JHDM2A, JHMD2A, JMJD1, JMJD1A, KDM2A, lysine demethylase 3A, lysine (K)-specific demethylase 3A, TGSA, TSGA, Zinc finger protein-putative |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kdm3a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- catalytic domain
- 2-oxoglutarate:oxygen oxidoreductase
- transcription cofactor
- androgen receptor binding
- iron ion binding
- chromatin binding
- protein binding
- histone demethylase activity
- RmlC-like cupin superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- non-insulin-dependent diabetes mellitus
- metastasis
- hepatic steatosis
- insulin resistance
- obesity
- weight gain
- colorectal cancer
- hyperlipidemia
- oligozoospermia
role in cell
- expression in
- apoptosis
- proliferation
- morphology
- binding in
- colony formation
- growth
- migration
- G1 phase
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
- acrosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kdm3a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spermatid nucleus elongation
- formaldehyde biosynthetic process
- chromatin remodeling
- positive regulation of transcription, DNA-dependent
- regulation of stem cell differentiation
- regulation of stem cell maintenance
- androgen receptor signaling pathway
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
- hormone-mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- membrane
- histone deacetylase complex
- chromatin
- male germ cell nucleus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- chromatin DNA binding
- protein binding
- transcription cofactor activity
- androgen receptor binding
- iron ion binding
- histone demethylase activity (H3-K9 specific)