Clk4 Gene Summary [Mouse]
Enables protein serine/threonine kinase activity and protein tyrosine kinase activity. Acts upstream of or within peptidyl-tyrosine phosphorylation and protein autophosphorylation. Located in nucleus. Is expressed in several structures, including endocrine gland; gonad; hemolymphoid system gland; liver; and tongue. Orthologous to human CLK4 (CDC like kinase 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Clk4 |
| Official Name | CDC like kinase 4 [Source:MGI Symbol;Acc:MGI:1098551] |
| Ensembl ID | ENSMUSG00000020385 |
| Bio databases IDs | |
| Aliases | CDC like kinase 4 |
| Synonyms | CDC-like kinase 4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Clk4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- catalytic domain
- Protein tyrosine and serine/threonine kinase
- protein binding
- protein-tyrosine kinase
- Protein kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Clk4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- Huntington disease
- colorectal cancer
- melanoma cancer
- myocardial hypertrophy
- melanoma
- glioblastoma
- glioblastoma cancer
- cardiac hypertrophy
- lung cancer
role in cell
- expression in
- hypertrophy
- serine phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Clk4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peptidyl-tyrosine phosphorylation
- regulation of RNA splicing
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein tyrosine kinase activity
- protein binding
- protein serine/threonine/tyrosine kinase activity
- protein serine/threonine kinase activity