Srsf10 Gene Summary [Mouse]
Predicted to enable RNA binding activity. Involved in RNA splicing, via transesterification reactions; cytosolic transport; and negative regulation of mRNA splicing, via spliceosome. Located in nucleoplasm. Is expressed in several structures, including branchial arch; central nervous system; foregut-midgut junction; sensory organ; and testis. Orthologous to human SRSF10 (serine and arginine rich splicing factor 10). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Srsf10 |
| Official Name | serine and arginine-rich splicing factor 10 [Source:MGI Symbol;Acc:MGI:1333805] |
| Ensembl ID | ENSMUSG00000028676 |
| Bio databases IDs | |
| Aliases | serine and arginine-rich splicing factor 10 |
| Synonyms | FUSIP1, FUSIP2, LOC100505793, LOC100996657, LOC642558, LOC727922, NSSR, NSSR1, NSSR2, PPP1R149, serine and arginine-rich splicing factor 10, SFRS13, SFRS13A, SRp38, SRrp40, Srsf13a, TASR, TASR1, TASR2, TLS-associated serine-arginine |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Srsf10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- arginine-serine-rich domain 3
- arginine-serine-rich domain 1
- RNA recognition motif
- protein binding
- arginine-serine-rich domain 2
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- edema
- neoplasia
- ventricular septal defect
- growth failure
- atrial septal defect
- complete atrioventricular septal defect
role in cell
- expression in
- colony formation by
- sphere formation by
- splicing by
- transport in
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nucleoli
- interchromatin granule clusters
- nuclear speckles
- perikaryon
- dendrites
- axon terminals
- paraspeckle-like structures
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Srsf10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing, via transesterification reactions
- negative regulation of nuclear mRNA splicing, via spliceosome
- cytoplasmic transport
- regulation of nuclear mRNA splicing, via spliceosome
- mRNA splice site selection
- regulation of transcription, DNA-dependent
- nuclear mRNA splicing, via spliceosome
- assembly of spliceosomal tri-snRNP
Cellular Component
Where in the cell the gene product is active
- nucleus
- dendrite
- cytoplasm
- nuclear speck
- cytosol
- neuronal cell body
- axon terminus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- unfolded protein binding
- RS domain binding