Eif4enif1 Gene Summary [Mouse]
Enables mRNA binding activity. Acts upstream of or within negative regulation of neuron differentiation; negative regulation of translation; and stem cell population maintenance. Located in P-body; cytosol; and nucleus. Is expressed in several structures, including cerebral cortex; early conceptus; epithelium; metanephros; and ovary. Orthologous to human EIF4ENIF1 (eukaryotic translation initiation factor 4E nuclear import factor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Eif4enif1 |
| Official Name | eukaryotic translation initiation factor 4E nuclear import factor 1 [Source:MGI Symbol;Acc:MGI:1921453] |
| Ensembl ID | ENSMUSG00000020454 |
| Bio databases IDs | |
| Aliases | eukaryotic translation initiation factor 4E nuclear import factor 1 |
| Synonyms | 2610509L04Rik, 4E-T, A930019J01RIK, Clast4, D11Ertd166e, eukaryotic translation initiation factor 4E nuclear import factor 1, RGD1560908 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Eif4enif1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E
- kinase binding
- mRNA binding
- protein binding
- eIF4E binding domain
- nuclear export signal receptor
- translation regulator
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- cytoplasmic mRNA processing body
- Nucleus
- cytoplasmic aggregates
- cytosol
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Eif4enif1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- stem cell maintenance
- nuclear export
- negative regulation of translation involved in gene silencing by miRNA
- neuron differentiation
- protein import into nucleus
- mRNA stabilization
- cytoplasmic mRNA processing body assembly
- negative regulation of neuron differentiation
- positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
- negative regulation of translation
- translation
Cellular Component
Where in the cell the gene product is active
- nucleus
- PML body
- cytoplasm
- nuclear speck
- intracellular membrane-bounded organelle
- membrane
- cytosol
- cytoplasmic mRNA processing body
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- mRNA binding
- kinase binding
- nuclear export signal receptor activity