Gigyf1 Gene Summary [Mouse]
Acts upstream of or within insulin-like growth factor receptor signaling pathway. Predicted to be part of protein-containing complex. Predicted to be active in cytosol. Is expressed in several structures, including genitourinary system; liver; lung; nervous system; and spleen. Orthologous to human GIGYF1 (GRB10 interacting GYF protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gigyf1 |
| Official Name | GRB10 interacting GYF protein 1 [Source:MGI Symbol;Acc:MGI:1888677] |
| Ensembl ID | ENSMUSG00000029714 |
| Bio databases IDs | |
| Aliases | GRB10 interacting GYF protein 1 |
| Synonyms | GRB10 interacting GYF protein 1, GYF1, mKIAA4110, PERQ1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gigyf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GYF
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- obesity
- pervasive developmental disorder
- gastric cancer
- neurodevelopmental disorder
- autoimmune thyroid disease
regulated by
role in cell
- migration
- apoptosis
- phosphorylation in
- expression in
- proliferation
- cell viability
- epithelial-mesenchymal transition
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gigyf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- insulin-like growth factor receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- cytosol
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- protein binding