Cox11 Gene Summary [Mouse]
Predicted to enable copper ion binding activity. Acts upstream of or within negative regulation of glucokinase activity. Located in mitochondrion. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 23. Orthologous to human COX11 (cytochrome c oxidase copper chaperone COX11). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cox11 |
| Official Name | cytochrome c oxidase assembly protein 11, copper chaperone [Source:MGI Symbol;Acc:MGI:1917052] |
| Ensembl ID | ENSMUSG00000020544 |
| Bio databases IDs | |
| Aliases | cytochrome c oxidase assembly protein 11, copper chaperone |
| Synonyms | 2010004I09RIK, COX11P, cytochrome c oxidase assembly protein 11, copper chaperone, cytochrome c oxidase copper chaperone COX11, LOC100910689, LOC688135, MC4DN23 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cox11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- electron carrier
- enzyme
- protein binding
- Cytochrome c oxidase assembly protein CtaG/Cox11
Pathways
Biological processes and signaling networks where the Cox11 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obsessive-compulsive disorder
- nuclear type 23 mitochondrial complex IV deficiency
- lung adenocarcinoma
- lung adenocarcinoma formation
- Huntington disease
regulates
- adenosine triphosphate
role in cell
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cox11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ATP biosynthetic process
- cellular cation homeostasis
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- macromolecular complex
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- copper ion binding
- electron carrier activity