Spag5 Gene Summary [Mouse]
Predicted to enable microtubule binding activity. Acts upstream of or within establishment of spindle orientation. Located in ciliary basal body; ciliary rootlet; and mitotic spindle. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Orthologous to human SPAG5 (sperm associated antigen 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Spag5 |
| Official Name | sperm associated antigen 5 [Source:MGI Symbol;Acc:MGI:1927470] |
| Ensembl ID | ENSMUSG00000002055 |
| Bio databases IDs | |
| Aliases | sperm associated antigen 5 |
| Synonyms | D11Bhm180e, DEEPEST, hMAP126, MAP126, Mastrin, S17, sperm associated antigen 5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Spag5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SPEC
- microtubule binding
- Autophagy protein 16 (ATG16)
- exonuclease SbcC
- peptidase
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- epithelial cancer
- gastric adenocarcinoma
- gastric epithelial cancer
- prostate cancer
- urothelial bladder carcinoma
- transitional cell bladder cancer
- hepatocellular carcinoma
- lung squamous cell carcinoma
- squamous cell lung cancer
regulates
- TP53
- RPTOR
role in cell
- apoptosis
- expression in
- organization
- assembly
- cohesion
- cohesion in
- misalignment in
- misalignment
- chromosomal congression
- segregation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- microtubule aster fraction
- spindle apparatus
- Cytoplasm
- basal bodies
- centrosome
- microtubules
- cytosol
- ciliary rootlet
- nuclear bodies
- spindle pole
- stress granule
- central spindle
- mitotic spindle
- kinetochores
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Spag5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- spindle organization
- regulation of metaphase plate congression
- positive regulation of intracellular transport
- mitotic sister chromatid segregation
- chromosome segregation
- establishment of spindle orientation
- regulation of attachment of spindle microtubules to kinetochore
- protein localization to centrosome
Cellular Component
Where in the cell the gene product is active
- ciliary rootlet
- nuclear body
- mitotic spindle
- cilium basal body
- cytoplasm
- microtubule plus end
- centriolar satellite
- cytosol
- kinetochore
- midbody
Molecular Function
What the gene product does at the molecular level
- protein binding
- microtubule binding