Laptm4a Gene Summary [Mouse]
Located in membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and hemolymphoid system gland. Orthologous to human LAPTM4A (lysosomal protein transmembrane 4 alpha). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Laptm4a |
| Official Name | lysosomal-associated protein transmembrane 4A [Source:MGI Symbol;Acc:MGI:108017] |
| Ensembl ID | ENSMUSG00000020585 |
| Bio databases IDs | |
| Aliases | lysosomal-associated protein transmembrane 4A |
| Synonyms | HUMORF13, LAPTM4, lysosomal-associated protein transmembrane 4A, lysosomal protein transmembrane 4 alpha, lysosomal protein transmembrane 4 α, MBNT, mKIAA0108, MTP, Mtrp |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Laptm4a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Golgi 4-transmembrane spanning transporter
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung adenocarcinoma
- lung adenocarcinoma formation
- EGFR mutation positive adenocarcinoma of the lung
- EGFR mutation positive non-small cell lung cancer
- EGFR expression positive non-squamous non-small cell lung cancer
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membranes
- cellular membrane
- Golgi Apparatus
- lysosome membrane
- endosomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Laptm4a gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- late endosome membrane
- Golgi apparatus
- lysosomal membrane
Molecular Function
What the gene product does at the molecular level
- protein binding