Eef1d Gene Summary [Mouse]
Predicted to enable several functions, including RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; guanyl-nucleotide exchange factor activity; and heat shock protein binding activity. Predicted to be involved in several processes, including cellular response to heat; cellular response to ionizing radiation; and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is active in glutamatergic synapse. Is expressed in cerebral cortex ventricular layer and cortical plate. Orthologous to human EEF1D (eukaryotic translation elongation factor 1 delta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Eef1d |
| Official Name | eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) [Source:MGI Symbol;Acc:MGI:1913906] |
| Ensembl ID | ENSMUSG00000055762 |
| Bio databases IDs | |
| Aliases | eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) |
| Synonyms | 1700026P12RIK, Eef1 δ, EF1B beta, EF1B β, EF-1D, EF-1-delta, EF-1-δ, eukaryotic translation elongation factor 1 delta, eukaryotic translation elongation factor 1 δ, FP1047, Tef1 delta, Tef1 δ, UNQ601, δ Ef1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Eef1d often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Eukaryotic elongation factor 1 beta central acidic region
- nucleic acid binding translation factor
- nucleic acid binding
- double-stranded DNA binding
- heat shock protein binding
- transcription factor binding
- protein binding
- zinc finger domain
- EF-1 guanine nucleotide exchange domain
- sequence-specific DNA binding
- EF1B
- translation regulator
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- idiopathic scoliosis
- myelodysplastic syndrome with isolated del(5q)
- acne
- neurodevelopmental disorder
- cold thyroid nodule
- Moyamoya disease
- autosomal recessive nonsyndromic mental retardation
role in cell
- migration
- phosphorylation in
- proliferation
- apoptosis
- growth
- quantity
- transformation
- development
- oncogenic potential
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- glutaminergic synapse
- fibrillar center
- endoplasmic reticulum mitochondria contact site
- Nucleus
- Endoplasmic Reticulum
- cytosol
- nucleoplasm
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Eef1d gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to ionizing radiation
- translational elongation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- endoplasmic reticulum
- fibrillar center
- eukaryotic translation elongation factor 1 complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- translation elongation factor activity
- cadherin binding
- guanyl-nucleotide exchange factor activity
- translation factor activity, nucleic acid binding