Arsg Gene Summary [Mouse]
Enables N-sulfoglucosamine-3-sulfatase activity and arylsulfatase activity. Acts upstream of or within several processes, including lysosome organization; neuron apoptotic process; and retina development in camera-type eye. Located in lysosome. Is expressed in central nervous system and retina. Used to study mucopolysaccharidosis. Human ortholog(s) of this gene implicated in Usher syndrome. Orthologous to human ARSG (arylsulfatase G). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arsg |
| Official Name | arylsulfatase G [Source:MGI Symbol;Acc:MGI:1921258] |
| Ensembl ID | ENSMUSG00000020604 |
| Bio databases IDs | |
| Aliases | arylsulfatase G |
| Synonyms | 6330406P08RIK, AI846872, arylsulfatase G, ASG, RGD1306571, USH4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Arsg often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- alkaline phosphatases and sulfatases
- Domain of unknown function (DUF4976)
- sulfuric ester hydrolase
- Sulfatase
- enzyme
- arylsulfatase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- bipolar disorder
- non-insulin-dependent diabetes mellitus
- usher syndrome type iv
- astrocytosis
- microgliosis
- Usher syndrome
- allergic rhinitis
- amyotrophic lateral sclerosis
regulates
- sulfur-containing compound
- sulfur
- 4-nitrocatechol sulfate
role in cell
- apoptosis
- number
- differentiation
- organization
- abnormal morphology
- degeneration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- vesicles
- lysosome
- Endoplasmic Reticulum
- endoplasmic reticulum lumen
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Arsg gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sulfur compound metabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- endoplasmic reticulum
- lysosome
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- arylsulfatase activity
- N-sulfoglucosamine-3-sulfatase activity