Cgrrf1 Gene Summary [Mouse]
Predicted to enable zinc ion binding activity. Predicted to be involved in negative regulation of cell growth. Predicted to be located in endoplasmic reticulum and nucleoplasm. Is expressed in several structures, including central nervous system; genitourinary system; and retina. Orthologous to human CGRRF1 (cell growth regulator with ring finger domain 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cgrrf1 |
| Official Name | cell growth regulator with ring finger domain 1 [Source:MGI Symbol;Acc:MGI:1916368] |
| Ensembl ID | ENSMUSG00000055128 |
| Bio databases IDs | |
| Aliases | cell growth regulator with ring finger domain 1 |
| Synonyms | 1110038G02Rik, 1810009H17Rik, cell growth regulator with ring finger domain 1, CGR19, RNF197 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cgrrf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- protein binding
- Zinc finger, C3HC4 type (RING finger)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- Endoplasmic Reticulum
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cgrrf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cell growth
- negative regulation of cell proliferation
- regulation of cell cycle
Cellular Component
Where in the cell the gene product is active
- intracellular membrane-bounded organelle
- endoplasmic reticulum
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding