Abca8b Gene Summary [Mouse]
Predicted to enable ABC-type xenobiotic transporter activity and lipid transporter activity. Predicted to be involved in several processes, including cholesterol efflux; positive regulation of cholesterol efflux; and sphingomyelin biosynthetic process. Predicted to act upstream of or within xenobiotic transmembrane transport. Located in basolateral plasma membrane. Is expressed in several structures, including alimentary system; eye; limb; male reproductive gland or organ; and nervous system. Orthologous to human ABCA8 (ATP binding cassette subfamily A member 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Abca8b |
| Official Name | ATP-binding cassette, sub-family A (ABC1), member 8b [Source:MGI Symbol;Acc:MGI:1351668] |
| Ensembl ID | ENSMUSG00000020620 |
| Bio databases IDs | |
| Aliases | ATP-binding cassette, sub-family A (ABC1), member 8b |
| Synonyms | Abca8, ATP-binding cassette, sub-family A member 8b |
| Species | Mouse, Mus musculus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Abca8b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ATPase activity, coupled to transmembrane movement of substances
- AAA domain, putative AbiEii toxin, Type IV TA system
- phosphonate ABC transporter, ATP-binding protein
- daunorubicin resistance ABC transporter ATP-binding subunit
- nitrate transport ATP-binding subunits C and D
- heme ABC exporter, ATP-binding protein CcmA
- urea ABC transporter, ATP-binding protein UrtE
- cobalt transport protein ATP-binding subunit
- gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit
- energy-coupling factor transporter ATPase
- xenobiotic-transporting ATPase
- nickel import ATP-binding protein NikE
- ABC transporter
- thiamine ABC transporter, ATP-binding protein
- P-loop containing Nucleoside Triphosphate Hydrolases
- transporter
- ATPases associated with a variety of cellular activities
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Endoplasmic Reticulum
- basolateral membrane