Rbm10 Gene Summary [Mouse]
Predicted to enable identical protein binding activity; miRNA binding activity; and single-stranded RNA binding activity. Acts upstream of or within negative regulation of RNA metabolic process; negative regulation of vascular associated smooth muscle cell proliferation; and positive regulation of vascular associated smooth muscle cell apoptotic process. Predicted to be located in nuclear speck. Predicted to be part of protein-containing complex. Predicted to be active in nucleolus. Is expressed in several structures, including branchial arch; central nervous system; early conceptus; oocyte; and sensory organ. Human ortholog(s) of this gene implicated in TARP syndrome; colorectal cancer; lung adenocarcinoma; and lung cancer. Orthologous to human RBM10 (RNA binding motif protein 10). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rbm10 |
| Official Name | RNA binding motif protein 10 [Source:MGI Symbol;Acc:MGI:2384310] |
| Ensembl ID | ENSMUSG00000031060 |
| Bio databases IDs | |
| Aliases | RNA binding motif protein 10 |
| Synonyms | D83948, DXS8237E, E430039K10Rik, FLJ10100, GPATC9, GPATCH9, MINAS-60, RNA binding motif protein 10, S1-1, TARPS, ZRANB5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rbm10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ELAV/HuD family splicing factor
- RNA recognition motif (RRM) superfamily
- G-patch domain
- Zn-finger in Ran binding protein and others
- RNA recognition motif
- OCRE domain
- protein binding
- zinc finger domain
- single-stranded RNA binding
- identical protein binding
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial neoplasia
- COVID-19
- epithelial cancer
- cancer
- TARP syndrome
- liver cancer
- hereditary disorder
- Wilms tumor
- Wilms tumorigenesis
- lung adenocarcinoma
role in cell
- proliferation
- expression in
- growth
- binding in
- splicing by
- reverse transcription in
- reverse transcription
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nucleoli
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rbm10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- 3'-UTR-mediated mRNA stabilization
- negative regulation of nuclear mRNA splicing, via spliceosome
- negative regulation of ribosomal large subunit export from nucleus
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear speck
- macromolecular complex
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- miRNA binding
- identical protein binding
- RNA binding
- protein binding
- metal ion binding