Psmd12 Gene Summary [Mouse]
Part of proteasome regulatory particle. Is expressed in several structures, including alimentary system; endocrine gland; ganglia; genitourinary system; and sensory organ. Orthologous to human PSMD12 (proteasome 26S subunit, non-ATPase 12). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Psmd12 |
| Official Name | proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 [Source:MGI Symbol;Acc:MGI:1914247] |
| Ensembl ID | ENSMUSG00000020720 |
| Bio databases IDs | |
| Aliases | proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 |
| Synonyms | 1500002F15Rik, LOC102552889, P55, proteasome 26S subunit, non-ATPase 12, proteasome (prosome, macropain) 26S subunit, non-ATPase, 12, PSD12, Rpn5, STISS |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Psmd12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
- PCI domain
- 26S proteasome regulatory subunit RPN5 C-terminal domain
- protein binding
Pathways
Biological processes and signaling networks where the Psmd12 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- neoplasia
- hepatocellular carcinoma
- liver cancer
- organismal death
- Stankiewicz-Isidor syndrome
- non-insulin-dependent diabetes mellitus
- hereditary disorder
- mammary neoplasm
- mental retardation
regulates
- ERK
- MEK
role in cell
- expression in
- cell death
- proliferation
- growth
- migration
- survival
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- secretory granule lumen
- ficolin-1-rich granule lumen
- Extracellular Space
- cytosol
- nucleoplasm
- clastosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Psmd12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- proteasome regulatory particle
- membrane
- cytosol
- proteasome complex
- secretory granule lumen
- proteasome accessory complex
- proteasome regulatory particle, lid subcomplex
- extracellular region
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding