Igf2bp1 Gene Summary [Mouse]
Enables mRNA 3'-UTR binding activity. Involved in positive regulation of cytoplasmic translation. Acts upstream of or within neuronal stem cell population maintenance and pallium cell proliferation in forebrain. Predicted to be located in several cellular components, including cytoplasmic ribonucleoprotein granule; dendritic spine; and neuronal cell body. Predicted to be part of CRD-mediated mRNA stability complex and ribonucleoprotein complex. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including central nervous system; eye; gonad; intestine; and limb. Orthologous to human IGF2BP1 (insulin like growth factor 2 mRNA binding protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Igf2bp1 |
| Official Name | insulin-like growth factor 2 mRNA binding protein 1 [Source:MGI Symbol;Acc:MGI:1890357] |
| Ensembl ID | ENSMUSG00000013415 |
| Bio databases IDs | |
| Aliases | insulin-like growth factor 2 mRNA binding protein 1 |
| Synonyms | CRD-BP, D030026A21Rik, D11Moh40e, D11Moh45, IMP-1, insulin-like growth factor 2 mRNA binding protein 1, LOC201194, mir-3063, Neilsen, VICKZ1, ZBP-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Igf2bp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- transcription regulator
- arCOG04150 universal archaeal KH domain protein
- RNA recognition motif
- mRNA binding
- protein binding activity, bridging
- K homology RNA-binding domain
- protein binding
- translation regulator
- mRNA 3' UTR binding
- mRNA 5' UTR binding
- KH domain
- K homology (KH) RNA-binding domain, type I
Pathways
Biological processes and signaling networks where the Igf2bp1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- cancer
- neoplasia
- breast cancer
- mammary neoplasm
- epithelial cancer
- diabetes mellitus
- tumorigenesis
- non-insulin-dependent diabetes mellitus
- lung adenocarcinoma
role in cell
- apoptosis
- cell death
- molecular cleavage in
- cell viability
- phosphorylation in
- expression in
- degradation in
- proliferation
- growth
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic mRNA processing body
- cell periphery
- Nucleus
- cytosol
- nucleoplasm
- dendritic spines
- growth cone
- neurites
- stress granule
- filopodia
- perikaryon
- axons
- dendrites
- lamellipodia
- paraspeckle-like structures
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Igf2bp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cytoplasmic translation
- negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
- nervous system development
- regulation of mRNA stability involved in response to stress
- regulation of cytokine production
- pallium cell proliferation in forebrain
- negative regulation of translation
- neuronal stem cell maintenance
- CRD-mediated mRNA stabilization
- mRNA transport
Cellular Component
Where in the cell the gene product is active
- CRD-mediated mRNA stability complex
- cytoplasmic stress granule
- cytoplasmic mRNA processing body
- neuronal cell body
- nucleoplasm
- growth cone
- nucleus
- perinuclear region of cytoplasm
- cytoplasm
- dendritic spine
- cytosol
- filopodium
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- translation regulator activity
- RNA binding
- protein binding
- mRNA 5'-UTR binding
- mRNA binding
- mRNA 3'-UTR binding