Nasp Gene Summary [Mouse]
Enables histone binding activity and histone chaperone activity. Involved in G1/S transition of mitotic cell cycle and blastocyst development. Acts upstream of or within DNA replication-dependent chromatin assembly. Located in cytoplasm and nucleus. Is expressed in several structures, including brain; extraembryonic component; heart ventricle; lung; and metanephros. Orthologous to human NASP (nuclear autoantigenic sperm protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nasp |
| Official Name | nuclear autoantigenic sperm protein (histone-binding) [Source:MGI Symbol;Acc:MGI:1355328] |
| Ensembl ID | ENSMUSG00000028693 |
| Bio databases IDs | |
| Aliases | nuclear autoantigenic sperm protein (histone-binding) |
| Synonyms | 5033430J04Rik, D4Ertd767e, Epcs32, FLB7527, HMDRA1, Nasp-T, nuclear autoantigenic sperm protein, nuclear autoantigenic sperm protein (histone-binding), PRO1999 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nasp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- binding protein
- Tetratricopeptide repeats
- nuclear localization sequence
- histone binding domain
- SHNi-TPR
- protein binding
- tetratricopeptide repeat
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lymphomagenesis
- renal cell carcinoma
- renal cell cancer
- MYC mutation positive B-cell lymphoma
- B cell cancer
- spinal stenosis
regulated by
- lipopolysaccharide
- geldanamycin
- NEF
- CD3 (complex)
- calcitriol
- Immunoglobulin
- Pc 3 cells
- CSNK2A1
- T lymphocytes
- megakaryocytes
role in cell
- expression in
- apoptosis
- proliferation
- phosphorylation in
- protection in
- cell cycle progression in
- assembly
- G1/S phase transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- perinuclear region
- nucleoplasm
- chromatin
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nasp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- male gonad development
- DNA replication
- blastocyst development
- protein transport
- response to testosterone stimulus
- CenH3-containing nucleosome assembly at centromere
- nucleosome assembly
- DNA replication-dependent nucleosome assembly
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- macromolecular complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- histone binding