Helz Gene Summary [Mouse]
Predicted to enable RNA binding activity. Predicted to be involved in regulatory ncRNA-mediated post-transcriptional gene silencing. Predicted to be located in nucleus. Predicted to be active in P granule and cytosol. Is expressed in retina outer nuclear layer. Orthologous to human HELZ (helicase with zinc finger). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Helz |
| Official Name | helicase with zinc finger domain [Source:MGI Symbol;Acc:MGI:1925705] |
| Ensembl ID | ENSMUSG00000020721 |
| Bio databases IDs | |
| Aliases | helicase with zinc finger domain |
| Synonyms | 3110078M01RIK, 9430093I07RIK, 9630002H22Rik, AI851979, DHRC, DRHC, helicase with zinc finger, helicase with zinc finger domain, HUMORF5, LOC284019 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Helz often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Type III restriction enzyme, res subunit
- N-terminal helicase domain of the DEAD-box helicase superfamily
- enzyme
- Zinc finger C-x8-C-x5-C-x3-H type (and similar)
- protein binding
- P-loop containing Nucleoside Triphosphate Hydrolases
- AAA domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- epithelial neoplasia
- cancer
- liver cancer
- cholangiocarcinoma cancer
- bile duct cancer
- liver neoplasia
- biliary tract cancer
- abdominal cancer
- digestive system cancer
regulated by
- GnRH analog
- SNCA
- mir-30 (includes others)
- curcumin
- T lymphocytes
- hematopoietic progenitor cells
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Helz gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- posttranscriptional gene silencing by RNA
Cellular Component
Where in the cell the gene product is active
- nucleus
- P granule
- membrane
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- RNA binding
- metal ion binding
- helicase activity
- hydrolase activity