Nup155 Gene Summary [Mouse]
Predicted to be a structural constituent of nuclear pore. Acts upstream of or within with a positive effect on miRNA processing and protein localization to nucleus. Acts upstream of or within atrial cardiac muscle cell action potential; mRNA export from nucleus; and protein import into nucleus. Located in nuclear envelope. Human ortholog(s) of this gene implicated in familial atrial fibrillation. Orthologous to human NUP155 (nucleoporin 155). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nup155 |
| Official Name | nucleoporin 155 [Source:MGI Symbol;Acc:MGI:2181182] |
| Ensembl ID | ENSMUSG00000022142 |
| Bio databases IDs | |
| Aliases | nucleoporin 155 |
| Synonyms | ATFB15, D930027M19Rik, mKIAA0791, N155, nucleoporin 155, Nucleoporin Nup155 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nup155 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Nup133 N terminal like
Pathways
Biological processes and signaling networks where the Nup155 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection by HIV-1
- familial atrial fibrillation type 15
role in cell
- expression in
- cell death
- proliferation
- survival
- association in
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- cytosol
- nuclear pores
- inner nuclear membrane
- nucleoplasm
- nuclear envelope
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nup155 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA export from nucleus
- nucleocytoplasmic transport
- regulation of atrial cardiac muscle cell action potential
- nuclear envelope organization
- RNA export from nucleus
- production of miRNAs involved in gene silencing by miRNA
- protein import into nucleus
- transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery
- protein targeting to nuclear inner membrane
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- nuclear membrane
- membrane
- cytosol
- nuclear pore
Molecular Function
What the gene product does at the molecular level
- protein binding
- structural constituent of nuclear pore