Slc25a19 Gene Summary [Mouse]
Enables thiamine pyrophosphate transmembrane transporter activity. Involved in thiamine diphosphate biosynthetic process. Located in mitochondrion. Is active in mitochondrial inner membrane. Is expressed in central nervous system; embryo; retina inner nuclear layer; retina layer; and retina outer nuclear layer. Human ortholog(s) of this gene implicated in inherited metabolic disorder and microcephaly. Orthologous to human SLC25A19 (solute carrier family 25 member 19). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc25a19 |
| Official Name | solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19 [Source:MGI Symbol;Acc:MGI:1914533] |
| Ensembl ID | ENSMUSG00000020744 |
| Bio databases IDs | |
| Aliases | solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19 |
| Synonyms | 2900089E13Rik, Deoxynucleotide carrier, DNC, MCPHA, MTPPT, MUP1, solute carrier family 25 member 19, solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19, THMD3, THMD4, TPC |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc25a19 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- organic cation transporter
- organophosphate ester transporter
- Mitochondrial carrier protein
- thiamin transporter
- organic anion transporter
- deoxynucleotide transporter
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- thiamine metabolism dysfunction syndrome 4
- exencephaly
- Amish lethal microcephaly
- ketoaciduria
- anemia
- Leigh syndrome
- microcephaly
regulates
- dTTP
- ddCDP
- adenosine triphosphate
- dTDP
- dATP
- dADP
- thiamin pyrophosphate
- dGDP
- ddTDP
- ddADP
role in cell
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc25a19 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- thiamine-containing compound metabolic process
- thiamine diphosphate biosynthetic process
- thiamine pyrophosphate transport
- deoxynucleotide transport
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrion
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- thiamine transmembrane transporter activity
- antiporter activity
- thiamine pyrophosphate transporter activity
- deoxynucleotide transmembrane transporter activity