Ten1 Gene Summary [Mouse]
Predicted to enable telomerase inhibitor activity and telomeric DNA binding activity. Predicted to be involved in negative regulation of telomere maintenance via telomerase. Located in chromosome, telomeric region and nucleus. Part of CST complex. Orthologous to human TEN1 (TEN1 subunit of CST complex). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ten1 |
| Official Name | TEN1 telomerase capping complex subunit [Source:MGI Symbol;Acc:MGI:1916785] |
| Ensembl ID | ENSMUSG00000020778 |
| Bio databases IDs | |
| Aliases | TEN1 telomerase capping complex subunit |
| Synonyms | 2310004N24Rik, C17orf106, RGD1311078, TEN1 subunit of CST complex, TEN1 telomerase capping complex subunit |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ten1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Telomere-capping, CST complex subunit
- protein binding
- telomeric DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- telomeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ten1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- telomere capping
- negative regulation of telomere maintenance via telomerase
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromosome, telomeric region
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- telomeric DNA binding
- telomerase inhibitor activity
- single-stranded DNA binding