Grin2c Gene Summary [Mouse]
Enables NMDA glutamate receptor activity; monoatomic cation channel activity; and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Involved in regulation of synaptic plasticity. Acts upstream of or within several processes, including excitatory postsynaptic potential; neuromuscular process controlling balance; and protein localization to postsynaptic membrane. Located in postsynaptic membrane. Part of NMDA selective glutamate receptor complex. Is active in glutamatergic synapse and postsynaptic density membrane. Is expressed in several structures, including brain; colon; eye; gallbladder; and genitourinary system. Orthologous to human GRIN2C (glutamate ionotropic receptor NMDA type subunit 2C). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Grin2c |
| Official Name | glutamate receptor, ionotropic, NMDA2C (epsilon 3) [Source:MGI Symbol;Acc:MGI:95822] |
| Ensembl ID | ENSMUSG00000020734 |
| Bio databases IDs | |
| Aliases | glutamate receptor, ionotropic, NMDA2C (epsilon 3) |
| Synonyms | GluN2C, glutamate ionotropic receptor NMDA type subunit 2C, glutamate receptor, ionotropic, NMDA2C (epsilon 3), glutamate receptor, ionotropic, NMDA2C (ε 3), NMDAR2C, NR2C |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Grin2c often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Receptor family ligand binding region
- channel/pore class transporter
- calcium channel
- Ligated ion channel L-glutamate- and glycine-binding site
- ionotropic glutamate receptor
- glutamate binding
- extracellular ligand-gated ion channel
- protein binding
- ion channel
- PDZ-domain binding
- N-methyl-D-aspartate selective glutamate receptor
- neurotransmitter receptor
- cytoplasmic domain
- Type 1 periplasmic binding fold superfamily
- Type 2 periplasmic binding fold superfamily
- ligand-gated ion channel
- cytosolic tail domain
- PDZ binding motif
- cation channel
- Bacterial extracellular solute-binding proteins, family 3
Pathways
Biological processes and signaling networks where the Grin2c gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Amyotrophic Lateral Sclerosis Signaling
- Calcium Signaling
- Circadian Rhythm Signaling
- CREB Signaling in Neurons
- Dopamine-DARPP32 Feedback in cAMP Signaling
- Ephrin Receptor Signaling
- Glutamate Receptor Signaling
- Neuroinflammation Signaling Pathway
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- nNOS Signaling in Neurons
- Opioid Signaling Pathway
- Reelin Signaling in Neurons
- Synaptic Long Term Potentiation
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- tuberculosis
- nausea
- pain
- multiple sclerosis
- ulcerative colitis
- Crohn disease
- schizophrenia
- depressive disorder
- allergy
- Alzheimer disease
role in cell
- transmembrane potential
- binding in
- growth
- cell death
- replication in
- depolarization
- inactivation in
- plasticity
- action potential in
- transmission
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- cellular membrane
- endoplasmic reticulum membrane
- postsynaptic membrane
- synaptic membrane
- neurites
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Grin2c gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of excitatory postsynaptic membrane potential
- response to wounding
- negative regulation of protein catabolic process
- brain development
- glutamate receptor signaling pathway
- regulation of neuronal synaptic plasticity
- regulation of synaptic plasticity
- positive regulation of excitatory postsynaptic membrane potential
- directional locomotion
- long-term synaptic potentiation
- positive regulation of synaptic transmission, glutamatergic
- calcium-mediated signaling
- ionotropic glutamate receptor signaling pathway
- neuromuscular process controlling balance
- synaptic transmission, glutamatergic
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- postsynaptic membrane
- N-methyl-D-aspartate selective glutamate receptor complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- glutamate-gated calcium ion channel activity
- N-methyl-D-aspartate selective glutamate receptor activity