Blmh Gene Summary [Mouse]
The encoded protein is a cytoplasmic cysteine peptidase involved in inactivation of bleomycin, a glycopeptide which is a component of combination chemotherapy regimens for cancer. This encoded enzyme is highly conserved, and it contains the signature active site residues of cysteine protease papain superfamily enzymes. It is postulated that this enzyme has protective effects against bleomycin-induced pulmonary fibrosis and bleomycin tumor resistance. [provided by RefSeq, Jan 2010]
Details
| Type | Protein Coding |
| Official Symbol | Blmh |
| Official Name | bleomycin hydrolase [Source:MGI Symbol;Acc:MGI:1345186] |
| Ensembl ID | ENSMUSG00000020840 |
| Bio databases IDs | |
| Aliases | bleomycin hydrolase |
| Synonyms | BH, BLEOMYCIN HYDROLASE, BLM hydrolase, BMH |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Blmh often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cysteine-type peptidase
- cysteine endopeptidase
- carboxypeptidase
- peptidase
- aminopeptidase
- Peptidase_C1
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- dermatitis
- organismal death
- lewy body disease
- relapsed testicular cancer
- fibrosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Nucleus
- Golgi Apparatus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Blmh gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- homocysteine catabolic process
- protein polyubiquitination
- proteolysis
- response to xenobiotic stimulus
- response to toxin
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- carboxypeptidase activity
- protein binding
- cysteine-type endopeptidase activity
- cysteine-type aminopeptidase activity
- cysteine-type peptidase activity
- aminopeptidase activity