Casp1 Gene Summary [Mouse]
Enables cysteine-type endopeptidase activity. Involved in several processes, including AIM2 inflammasome complex assembly; positive regulation of canonical NF-kappaB signal transduction; and positive regulation of interleukin-1 beta production. Acts upstream of or within several processes, including membrane hyperpolarization; mitochondrial depolarization; and positive regulation of cytokine production. Located in extracellular region. Part of IPAF inflammasome complex. Is active in cytosol. Is expressed in several structures, including forelimb mesenchyme; knee joint; oocyte; small intestine; and telencephalon. Orthologous to human CASP1 (caspase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Casp1 |
| Official Name | caspase 1 [Source:MGI Symbol;Acc:MGI:96544] |
| Ensembl ID | ENSMUSG00000025888 |
| Bio databases IDs | |
| Aliases | caspase 1 |
| Synonyms | caspase 1, ICE, Il1bc, Procaspase-1 |
| Species | Mouse, Mus musculus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Casp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CARD domain binding
- CASc
- Caspase recruitment domain
- endopeptidase
- cysteine endopeptidase
- cytokine binding
- kinase binding
- peptidase
- protein binding
- Death Domain Superfamily of protein-protein interaction domains
- identical protein binding
Pathways
Biological processes and signaling networks where the Casp1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Amyotrophic Lateral Sclerosis Signaling
- DNA damage-induced 14-3-3σ Signaling
- Endocannabinoid Cancer Inhibition Pathway
- Endothelin-1 Signaling
- Granzyme A Signaling
- Huntington's Disease Signaling
- Inflammasome pathway
- Neuroinflammation Signaling Pathway
- Osteoarthritis Pathway
- Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza
- Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
- Role of PKR in Interferon Induction and Antiviral Response
- Sphingosine-1-phosphate Signaling
- TREM1 Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection
- fibrosis
- obesity
- neoplasia
- gastrointestinal neoplasia
- colitis
- ulcerative colitis
- colorectal neoplasia
- gastritis
- cancer
role in cell
- expression in
- size
- proliferation
- number
- quantity
- differentiation
- processing in
- phosphorylation in
- accumulation
- accumulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- cytosol