Fbxl20 Gene Summary [Mouse]
Involved in regulation of protein catabolic process at presynapse, modulating synaptic transmission and regulation of synaptic vesicle exocytosis. Acts upstream of or within behavioral fear response. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is expressed in several structures, including adrenal gland; brain; genitourinary system; gut; and respiratory system. Orthologous to human FBXL20 (F-box and leucine rich repeat protein 20). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fbxl20 |
| Official Name | F-box and leucine-rich repeat protein 20 [Source:MGI Symbol;Acc:MGI:1919444] |
| Ensembl ID | ENSMUSG00000020883 |
| Bio databases IDs | |
| Aliases | F-box and leucine-rich repeat protein 20 |
| Synonyms | 2610511F20RIK, 4632423N09Rik, Fbl2, Fbl20, F-box and leucine-rich repeat protein 20, Fbxl2, LOC90110, mKIAA4147, Scr |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fbxl20 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- F-box domain
- protein phosphatase 1 regulatory subunit 42
- F-box domain superfamily
- Leucine-rich repeat - CC (cysteine-containing) subfamily
- F-box-like
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- coronary artery disease
- albuminuria
- kidney stones
- asthma
- peptic ulcer disease
- primary biliary cirrhosis
- substance-related disorder
- cardiovascular disorder
- microalbuminuria
role in cell
- expression in
- degradation in
- apoptosis
- autophagy in
- paired-pulse facilitation
- camptothecin sensitivity
- doxorubicin sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- cytosol
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fbxl20 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of synaptic vesicle exocytosis
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
- behavioral fear response
Cellular Component
Where in the cell the gene product is active
- cytosol
- SCF ubiquitin ligase complex
Molecular Function
What the gene product does at the molecular level
- protein binding