Ptger4 Gene Summary [Mouse]
Predicted to enable prostaglandin E receptor activity. Involved in several processes, including T-helper cell differentiation; cellular response to mechanical stimulus; and regulation of cytokine production. Acts upstream of or within several processes, including regulation of ossification; response to lipopolysaccharide; and response to nematode. Predicted to be located in neuron projection terminus; neuronal cell body; and nuclear membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including arterial system; central nervous system; genitourinary system; heart valve; and skin. Used to study dilated cardiomyopathy. Human ortholog(s) of this gene implicated in ankylosing spondylitis; arteriosclerosis; and ulcerative colitis. Orthologous to human PTGER4 (prostaglandin E receptor 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Ptger4 |
| Official Name | prostaglandin E receptor 4 (subtype EP4) [Source:MGI Symbol;Acc:MGI:104311] |
| Ensembl ID | ENSMUSG00000039942 |
| Bio databases IDs | |
| Aliases | prostaglandin E receptor 4 (subtype EP4) |
| Synonyms | EP4, EP4R, prostaglandin E receptor 4, prostaglandin E receptor 4 (subtype EP4), Ptger, Ptgerep4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ptger4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- prostaglandin E receptor
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Ptger4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- macular degeneration
- experimental autoimmune encephalomyelitis
- neoplasia
- cancer
- squamous cell cancer
- epithelial cancer
- weight gain
- arthritis
- congestion
- osteoarthritis
role in cell
- expression in
- proliferation
- differentiation
- apoptosis
- activation in
- function
- production in
- phosphorylation in
- activation
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- Cytoplasm
- cell surface
- perinuclear region
- cellular membrane
- Nucleus
- primary cilia
- nuclear envelope
- nerve ending
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ptger4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of inflammatory response
- positive regulation of inflammatory response
- regulation of stress fiber assembly
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway
- JNK cascade
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- cellular response to prostaglandin E stimulus
- response to nematode
- bone development
- elevation of cytosolic calcium ion concentration
- response to mechanical stimulus
- ERK1 and ERK2 cascade
- T-helper cell differentiation
- inflammatory response
- cellular response to mechanical stimulus
- immune response
- negative regulation of eosinophil extravasation
- response to lipopolysaccharide
- negative regulation of cytokine production
- regulation of ossification
- positive regulation of cytokine production
- negative regulation of integrin activation
Cellular Component
Where in the cell the gene product is active
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- prostaglandin E receptor activity