Smoc1 Gene Summary [Mouse]
Enables extracellular matrix binding activity. Involved in eye development and limb development. Acts upstream of or within extracellular matrix organization and positive regulation of cell-substrate adhesion. Located in basement membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hindlimb; and sensory organ. Used to study microphthalmia with limb anomalies. Human ortholog(s) of this gene implicated in microphthalmia with limb anomalies. Orthologous to human SMOC1 (SPARC related modular calcium binding 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Smoc1 |
| Official Name | SPARC related modular calcium binding 1 [Source:MGI Symbol;Acc:MGI:1929878] |
| Ensembl ID | ENSMUSG00000021136 |
| Bio databases IDs | |
| Aliases | SPARC related modular calcium binding 1 |
| Synonyms | 2600002F22Rik, OAS, SPARC related modular calcium binding 1, SRG |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Smoc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EFh_SPARC_EC
- Thyroglobulin_1 repeat associated disordered domain
- TY
- extracellular matrix binding
- protein binding
- KAZAL_FS
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- Ca2+
- ITGB3
disease
- non-insulin-dependent diabetes mellitus
- lung adenocarcinoma
- lung adenocarcinoma formation
- microphthalmia with limb anomalies
- B cell cancer
- atherosclerosis
- hereditary disorder
- plasma cell neoplasm
- mature B-cell neoplasia
- osteoporosis
phenotypes
- abnormal behavior
- abnormal coat/hair pigmentation
- abnormal cranium morphology
- abnormal digit morphology
- abnormal gait
- abnormal head size
- abnormal maxilla morphology
- abnormal pelvic girdle bone morphology
- abnormal snout morphology
- decreased circulating HDL cholesterol level
- decreased circulating amylase level
- decreased circulating iron level
- decreased erythrocyte cell number
- decreased mean corpuscular hemoglobin
- decreased total body fat amount
- hyperactivity
- hypoactivity
- increased anxiety-related response
- increased mean platelet volume
- increased red blood cell distribution width
- increased thigmotaxis
- preweaning lethality incomplete penetrance
- short tibia
- syndactyly
- abnormal autopod morphology
- abnormal hindlimb morphology
- abnormal interdigital cell death
- abnormal joint morphology
- abnormal platelet volume
- abnormal pollex morphology
- abnormal retina morphology
- abnormal retinal pigment epithelium morphology
- absent fibula
- absent optic nerve
- bowed tibia
- cleft palate
- clubfoot
- decreased body size
- decreased body weight
- decreased embryo size
- decreased retinal ganglion cell number
- fused metatarsal bones
- high palate
- interdigital webbing
- iris coloboma
- microphthalmia
- neonatal lethality complete penetrance
- optic nerve hypoplasia
- postnatal growth retardation
- postnatal lethality complete penetrance
- retina coloboma
- retinal degeneration
- short fibula
- synostosis
role in cell
- phosphorylation in
- organization
- differentiation
- aggregation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- zona pellucida
- extracellular matrix
- lamina lucida
- basement membrane
- lamina fibroreticularis
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Smoc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- eye development
- limb development
- extracellular matrix organization
- cell differentiation
- regulation of osteoblast differentiation
Cellular Component
Where in the cell the gene product is active
- basement membrane
- extracellular space
Molecular Function
What the gene product does at the molecular level
- extracellular matrix binding
- protein binding
- calcium ion binding
- heparin binding