Dpf3 Gene Summary [Mouse]
Predicted to enable zinc ion binding activity. Involved in muscle cell differentiation and nervous system development. Part of nBAF complex. Is expressed in several structures, including central nervous system; gonad; heart; retina; and urinary system. Orthologous to human DPF3 (double PHD fingers 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dpf3 |
| Official Name | D4, zinc and double PHD fingers, family 3 [Source:MGI Symbol;Acc:MGI:1917377] |
| Ensembl ID | ENSMUSG00000021221 |
| Bio databases IDs | |
| Aliases | D4, zinc and double PHD fingers, family 3 |
| Synonyms | 2810403B03Rik, 6530402L11RIK, BAF45C, CERD4, double PHD fingers 3, Gm18872, LOC100502642, LOC102553599, RGD1563913, SMARCG3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dpf3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PHD zinc finger
- PHD finger superfamily
- protein binding
- DPF1-3, N-terminal
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- major depression
- epithelial cancer
- systemic lupus erythematosus
- gout
- atrial fibrillation
- idiopathic scoliosis
- renal cell carcinoma
- renal cell cancer
- renal clear cell adenocarcinoma
- renal clear cell cancer
role in cell
- growth
- migration
- differentiation
- binding in
- acetylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dpf3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- muscle organ development
- chromatin remodeling
- regulation of mitotic metaphase/anaphase transition
- nervous system development
- positive regulation of myoblast differentiation
- regulation of G1/S transition of mitotic cell cycle
- positive regulation of cell differentiation
- positive regulation of double-strand break repair
- regulation of nucleotide-excision repair
- regulation of transcription from RNA polymerase II promoter
- regulation of G0 to G1 transition
Cellular Component
Where in the cell the gene product is active
- SWI/SNF complex
- nBAF complex
- brahma complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding