Dpf1 Gene Summary [Mouse]
Predicted to enable sequence-specific double-stranded DNA binding activity. Involved in nervous system development. Part of nBAF complex. Is expressed in several structures, including eye; genitourinary system; limb; nervous system; and submandibular gland. Orthologous to human DPF1 (double PHD fingers 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dpf1 |
| Official Name | D4, zinc and double PHD fingers family 1 [Source:MGI Symbol;Acc:MGI:1352748] |
| Ensembl ID | ENSMUSG00000030584 |
| Bio databases IDs | |
| Aliases | D4, zinc and double PHD fingers family 1 |
| Synonyms | BAF45b, double PHD fingers 1, NEUD4, neuro-d4, SMARCG1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dpf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PHD zinc finger
- double-stranded DNA binding
- PHD finger superfamily
- protein binding
- DPF1-3, N-terminal
- sequence-specific DNA binding
Pathways
Biological processes and signaling networks where the Dpf1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dpf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of mitotic metaphase/anaphase transition
- chromatin remodeling
- apoptotic process
- nervous system development
- positive regulation of cell differentiation
- regulation of G1/S transition of mitotic cell cycle
- positive regulation of double-strand break repair
- regulation of nucleotide-excision repair
- regulation of G0 to G1 transition
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- nBAF complex
- chromatin
Molecular Function
What the gene product does at the molecular level
- metal ion binding