Actl6a Gene Summary [Mouse]
Enables chromatin binding activity. Involved in several processes, including positive regulation of DNA metabolic process; regulation of embryonic development; and telomere maintenance. Acts upstream of or within blastocyst formation and chromatin remodeling. Located in nucleus. Part of SWI/SNF complex and npBAF complex. Is expressed in several structures, including central nervous system; genitourinary system; lung; nose; and tooth. Orthologous to human ACTL6A (actin like 6A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Actl6a |
| Official Name | actin-like 6A [Source:MGI Symbol;Acc:MGI:1861453] |
| Ensembl ID | ENSMUSG00000027671 |
| Bio databases IDs | |
| Aliases | actin-like 6A |
| Synonyms | 2810432C06Rik, Actin-like 6a, ACTL6, ARP4, ARPN-BETA, ARPN-β, Baf53, BAF53A, INO80K, RGD1307747, SMARCN1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Actl6a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Actin
- chromatin binding
- protein binding
- ASKHA_ATPase-like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung cancer
- small cell lung cancer
- BAFopathy
- systemic sclerosis
- rheumatoid arthritis
- aplastic anemia
- bone marrow failure
- gastric cancer
role in cell
- expression in
- proliferation
- accumulation in
- survival
- G2/M phase
- cell cycle progression
- ferroptosis
- cellularity
- disruption
- compaction
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- nuclear fraction
- Cytoplasm
- Plasma Membrane
- nucleosomes
- nucleoplasm
- nuclear matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Actl6a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- regulation of mitotic metaphase/anaphase transition
- regulation of chromosome organization
- regulation of DNA strand elongation
- regulation of DNA repair
- positive regulation of cell proliferation
- nervous system development
- positive regulation of myoblast differentiation
- regulation of nucleotide-excision repair
- spinal cord development
- chromatin remodeling
- negative regulation of cell differentiation
- regulation of double-strand break repair
- positive regulation of transcription, DNA-dependent
- neural retina development
- blastocyst formation
- regulation of cell cycle
- positive regulation of DNA repair
- signal transduction
- DNA recombination
- regulation of embryonic development
- regulation of transcription, DNA-dependent
- telomere maintenance
- regulation of apoptotic process
- regulation of DNA replication
- positive regulation of cell differentiation
- regulation of transcription from RNA polymerase II promoter
- positive regulation of T cell differentiation
- regulation of G1/S transition of mitotic cell cycle
- positive regulation of double-strand break repair
- regulation of G0 to G1 transition
Cellular Component
Where in the cell the gene product is active
- SWI/SNF complex
- NuA4 histone acetyltransferase complex
- brahma complex
- kinetochore
- nucleosome
- chromatin
- plasma membrane
- nucleoplasm
- nucleus
- npBAF complex
- nuclear matrix
- macromolecular complex
- Ino80 complex
- RSC complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription coactivator activity
- nucleosomal DNA binding
- chromatin binding