Dpf2 Gene Summary [Mouse]
Predicted to enable histone H3K9me2/3 reader activity and lysine-acetylated histone binding activity. Predicted to be involved in negative regulation of myeloid progenitor cell differentiation and nervous system development. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 7. Orthologous to human DPF2 (double PHD fingers 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dpf2 |
| Official Name | D4, zinc and double PHD fingers family 2 [Source:MGI Symbol;Acc:MGI:109529] |
| Ensembl ID | ENSMUSG00000024826 |
| Bio databases IDs | |
| Aliases | D4, zinc and double PHD fingers family 2 |
| Synonyms | 2210010M07RIK, BAF45D, CSS7, double PHD fingers 2, REQ, Requiem, SMARCG2, UBID4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dpf2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Kruppel-type zinc finger domain
- PHD zinc finger
- histone binding
- transcription regulator
- transcription co-repressor
- nuclear localization sequence
- protein binding activity, bridging
- PHD finger superfamily
- DPF1-3, N-terminal
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Coffin-Siris syndrome type 7
- Coffin-Siris syndrome
- autosomal dominant mental retardation type 12
- hereditary disorder
role in cell
- apoptosis
- expression in
- growth
- differentiation
- binding in
- transactivation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- Cytoplasm
- centrosome
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dpf2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- chromatin remodeling
- regulation of mitotic metaphase/anaphase transition
- apoptotic process
- nervous system development
- apoptotic signaling pathway
- regulation of G1/S transition of mitotic cell cycle
- regulation of nucleotide-excision repair
- positive regulation of double-strand break repair
- regulation of transcription from RNA polymerase II promoter
- regulation of G0 to G1 transition
Cellular Component
Where in the cell the gene product is active
- SWI/SNF complex
- nucleus
- centrosome
- intracellular membrane-bounded organelle
- cytosol
- nBAF complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- transcription corepressor activity
- histone acetyl-lysine binding