Angel1 Gene Summary [Mouse]
Predicted to enable eukaryotic initiation factor 4E binding activity; mRNA 3'-UTR binding activity; and protein domain specific binding activity. Predicted to be located in several cellular components, including cis-Golgi network; endoplasmic reticulum; and perinuclear region of cytoplasm. Is expressed in cerebral cortex marginal layer; dorsal root ganglion; orbito-sphenoid; and trigeminal ganglion. Orthologous to human ANGEL1 (angel homolog 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Angel1 |
| Official Name | angel homolog 1 [Source:MGI Symbol;Acc:MGI:1915987] |
| Ensembl ID | ENSMUSG00000021257 |
| Bio databases IDs | |
| Aliases | angel homolog 1 |
| Synonyms | 1110030H02Rik, angel homolog 1, CCR4E, KIAA0759, mKIAA0759, RGD1306238 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Angel1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
- Endonuclease/Exonuclease/phosphatase family
- protein domain specific binding
- protein binding
- eukaryotic initiation factor 4E binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- perinuclear region
- Nucleus
- Endoplasmic Reticulum
- cytosol
- cis Golgi networks
- mitochondrial outer membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Angel1 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- nucleus
- cis-Golgi network
- perinuclear region of cytoplasm
- cytosol
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- 3'-5'-exoribonuclease activity
- protein domain specific binding
- eukaryotic initiation factor 4E binding