ANGEL1 Gene Summary [Human]
Enables eukaryotic initiation factor 4E binding activity and protein domain specific binding activity. Predicted to be involved in RNA phosphodiester bond hydrolysis, exonucleolytic. Located in several cellular components, including cis-Golgi network; endoplasmic reticulum; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ANGEL1 |
| Official Name | angel homolog 1 [Source:HGNC Symbol;Acc:HGNC:19961] |
| Ensembl ID | ENSG00000013523 |
| Bio databases IDs | |
| Aliases | angel homolog 1 |
| Synonyms | 1110030H02Rik, angel homolog 1, CCR4E, KIAA0759, mKIAA0759, RGD1306238 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ANGEL1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
- Endonuclease/Exonuclease/phosphatase family
- protein domain specific binding
- protein binding
- eukaryotic initiation factor 4E binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- perinuclear region
- Nucleus
- Endoplasmic Reticulum
- cytosol
- cis Golgi networks
- mitochondrial outer membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ANGEL1 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- nucleus
- cis-Golgi network
- perinuclear region of cytoplasm
- cytosol
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- 3'-5'-exoribonuclease activity
- protein domain specific binding
- eukaryotic initiation factor 4E binding