Gpld1

Enables glycosylphosphatidylinositol phospholipase D activity and sodium channel regulator activity. Involved in several processes, including positive regulation of high-density lipoprotein particle clearance; positive regulation of insulin secretion involved in cellular response to glucose stimulus; and regulation of primary metabolic process. Located in several cellular components, including extracellular matrix; extracellular space; and intracellular membrane-bounded organelle. Is expressed in several structures, including alimentary system; central nervous system; ear; genitourinary system; and skeleton. Orthologous to human GPLD1 (glycosylphosphatidylinositol specific phospholipase D1). [provided by Alliance of Genome Resources, Apr 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gpld1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Gpld1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Gpld1 gene, providing context for its role in the cell.