Gpld1 Gene Summary [Rat]
Enables glycosylphosphatidylinositol phospholipase D activity. Predicted to be involved in several processes, including cell migration involved in sprouting angiogenesis; cell surface receptor signaling pathway; and positive regulation of metabolic process. Located in extracellular space. Orthologous to human GPLD1 (glycosylphosphatidylinositol specific phospholipase D1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gpld1 |
| Official Name | glycosylphosphatidylinositol specific phospholipase D1 [Source:RGD Symbol;Acc:631371] |
| Ensembl ID | ENSRNOG00000017702 |
| Bio databases IDs | |
| Aliases | glycosylphosphatidylinositol specific phospholipase D1 |
| Synonyms | 6330541J12Rik, glycosylphosphatidylinositol specific phospholipase D1, GPI-PLD, GPIPLDM, PHOSPHOINOSITOL-GLYCAN-SPECIFIC PHOSPHOLIPASE D, PIGPLD, PIGPLD1, PLD |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gpld1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Integrin alpha (beta-propellor repeats)
- phospholipase D
- Zinc dependent phospholipase C/S1-P1 nuclease
- glycoprotein phospholipase D
- sodium channel regulator
- enzyme
- FG-GAP repeat
- protein binding
- FG-GAP-like repeat
Pathways
Biological processes and signaling networks where the Gpld1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- diabetic nephropathy
- androgenic alopecia
role in cell
- proliferation
- apoptosis
- migration
- migration by
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- Extracellular Space
- cytosol
- extracellular matrix
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gpld1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cellular response to insulin stimulus
- insulin receptor signaling pathway
- negative regulation of cell proliferation
- chondrocyte differentiation
- cell migration involved in sprouting angiogenesis
- cellular response to insulin stimulus
- response to glucose stimulus
- positive regulation of secretion
- positive regulation of membrane protein ectodomain proteolysis
- cellular response to calcium ion
- ossification
- cellular response to cholesterol
- negative regulation of triglyceride catabolic process
- positive regulation of insulin secretion involved in cellular response to glucose stimulus
- positive regulation of endothelial cell migration
- positive regulation of alkaline phosphatase activity
- complement receptor mediated signaling pathway
- hematopoietic stem cell migration to bone marrow
- positive regulation of glucose metabolic process
- phosphatidylcholine metabolic process
- positive regulation of triglyceride biosynthetic process
- GPI anchor release
- positive regulation of apoptotic process
- hematopoietic stem cell migration
- transepithelial transport
- cellular response to xenobiotic stimulus
- cellular response to pH
- cellular response to triglyceride
- positive regulation of high-density lipoprotein particle clearance
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- cytoplasm
- intracellular membrane-bounded organelle
- extracellular matrix
- extracellular region
- lysosomal membrane
Molecular Function
What the gene product does at the molecular level
- sodium channel regulator activity
- phospholipase D activity
- glycosylphosphatidylinositol phospholipase D activity