Id4 Gene Summary [Mouse]
Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in circadian rhythm. Acts upstream of or within several processes, including gland morphogenesis; negative regulation of cell differentiation; and nervous system development. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; immune system; sensory organ; and urinary system. Used to study osteoporosis. Orthologous to human ID4 (inhibitor of DNA binding 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Id4 |
| Official Name | inhibitor of DNA binding 4 [Source:MGI Symbol;Acc:MGI:99414] |
| Ensembl ID | ENSMUSG00000021379 |
| Bio databases IDs | |
| Aliases | inhibitor of DNA binding 4 |
| Synonyms | bHLHb27, IDB4, inhibitor of DNA binding 4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Id4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- basic Helix Loop Helix (bHLH) domain superfamily
- helix loop helix domain
- transcription factor binding
- protein binding
- helix-loop-helix domain
Pathways
Biological processes and signaling networks where the Id4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- adenoma formation
- Huntington disease
- osteogenesis imperfecta type III
- metastasis
- HER2 negative hormone receptor negative breast cancer
- cholesteatoma
- psoriasis
- androgenic alopecia
- pituitary gland adenoma
- head and neck neuroendocrine neoplasia
role in cell
- expression in
- proliferation
- cell death
- differentiation
- migration
- invasion by
- invasion
- adhesion
- survival
- colony formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Id4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- astrocyte differentiation
- prostate gland epithelium morphogenesis
- protein localization
- negative regulation of fat cell differentiation
- negative regulation of neuron differentiation
- negative regulation of astrocyte differentiation
- positive regulation of neuroblast proliferation
- hippocampus development
- fat cell differentiation
- positive regulation of transcription from RNA polymerase II promoter
- prostate gland stromal morphogenesis
- negative regulation of oligodendrocyte differentiation
- cerebral cortex neuron differentiation
- negative regulation of transcription from RNA polymerase II promoter
- central nervous system myelination
- neuroblast proliferation
- circadian regulation of gene expression
- negative regulation of transcription, DNA-dependent
- positive regulation of gene expression
- G1/S transition of mitotic cell cycle
- osteoblast differentiation
- cell differentiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein dimerization activity