Lyl1 Gene Summary [Mouse]
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in B cell differentiation and definitive hemopoiesis. Predicted to be located in nucleus. Is expressed in central nervous system; genitourinary system; heart; liver; and thymus primordium. Human ortholog(s) of this gene implicated in T-cell acute lymphoblastic leukemia. Orthologous to human LYL1 (LYL1 basic helix-loop-helix family member). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lyl1 |
| Official Name | lymphoblastomic leukemia 1 [Source:MGI Symbol;Acc:MGI:96891] |
| Ensembl ID | ENSMUSG00000034041 |
| Bio databases IDs | |
| Aliases | lymphoblastomic leukemia 1 |
| Synonyms | bHLHa18, LOC100365743, LYL1 basic helix-loop-helix family member, LYL1, basic helix-loop-helix family member, lymphoblastomic leukaemia 1, lymphoblastomic leukemia 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lyl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- basic Helix Loop Helix (bHLH) domain superfamily
- helix loop helix domain
- helix-loop-helix domain
- protein binding
- Helix-loop-helix DNA-binding domain
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- T acute lymphoblastic leukemia
- androgenic alopecia
- thrombocytopenia
- global developmental delay
role in cell
- differentiation
- expression in
- apoptosis
- activation in
- quantity
- growth
- colony formation by
- repopulation by
- binding in
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lyl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- B cell differentiation
- positive regulation of transcription, DNA-dependent
- blood vessel maturation
- regulation of transcription, DNA-dependent
- definitive hemopoiesis
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- protein dimerization activity
- sequence-specific DNA binding RNA polymerase II transcription factor activity