Ecsit Gene Summary [Mouse]
Enables DNA-binding transcription factor activity and chromatin binding activity. Acts upstream of or within BMP signaling pathway; mesoderm formation; and regulation of transcription by RNA polymerase II. Located in mitochondrion. Part of transcription regulator complex. Is expressed in several structures, including egg cylinder; embryo mesoderm; and genitourinary system. Orthologous to human ECSIT (ECSIT signaling integrator). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ecsit |
| Official Name | ECSIT signalling integrator [Source:MGI Symbol;Acc:MGI:1349469] |
| Ensembl ID | ENSMUSG00000066839 |
| Bio databases IDs | |
| Aliases | ECSIT signalling integrator |
| Synonyms | ECSIT signaling integrator, ECSIT signalling integrator, SITPEC |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ecsit often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- activation domain
- transcription regulator
- Evolutionarily conserved signalling intermediate in Toll pathway
- C-terminal domain of the ECSIT protein
- chromatin binding
- protein binding
- transcription factor activity
Pathways
Biological processes and signaling networks where the Ecsit gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- gastrointestinal neoplasia
role in cell
- quantity
- production in
- expression in
- proliferation
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Mitochondria
- cytosol
- mitochondrial inner membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ecsit gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of oxidoreductase activity
- innate immune response
- toll-like receptor 4 signaling pathway
- mitochondrial respiratory chain complex I assembly
- transmembrane receptor protein serine/threonine kinase signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- mitochondrion
- cytosol
- mitochondrial inner membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- binding, bridging