Cd47 Gene Summary [Mouse]
Predicted to enable protein binding activity involved in heterotypic cell-cell adhesion and thrombospondin receptor activity. Involved in positive regulation of activation-induced cell death of T cells; regulation of nitric oxide biosynthetic process; and regulation of synapse pruning. Acts upstream of or within several processes, including monocyte aggregation; opsonization; and positive regulation of phagocytosis. Located in extracellular exosome and plasma membrane. Is active in glutamatergic synapse and presynapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human CD47 (CD47 molecule). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cd47 |
| Official Name | CD47 antigen (Rh-related antigen, integrin-associated signal transducer) [Source:MGI Symbol;Acc:MGI:96617] |
| Ensembl ID | ENSMUSG00000055447 |
| Bio databases IDs | |
| Aliases | CD47 antigen (Rh-related antigen, integrin-associated signal transducer) |
| Synonyms | 9130415E20RIK, AA407862, B430305P08RIK, CD47 ANTIGEN, CD47 antigen (Rh-related antigen, integrin-associated signal transducer), CD47 molecule, CDw149, IAP, Itgp, LOC105374030, Locuslink 71587, MER6, OA3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cd47 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- signaling receptor activity
- immunoglobulin domain
- ectodomain
- cell adhesion molecule binding
- immunoglobulin variable region-like domain
- protein binding
- Ig-like V domain
- multiple membrane-spanning domain
- binding protein
- cytosolic tail domain
- transmembrane receptor
- CD47 transmembrane region
Pathways
Biological processes and signaling networks where the Cd47 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- peripheral T-cell lymphoma
- cancer
- anemia
- multiple sclerosis
- neoplasia
- T-cell non-Hodgkin disease
- metastatic gastric adenocarcinoma
- psoriasis
- acute myeloid leukemia
- myelodysplastic syndrome
role in cell
- cellular infiltration
- quantity
- expression in
- apoptosis
- phosphorylation in
- cell spreading
- dissemination
- activation in
- function
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- secondary granule fractions
- membrane fraction
- detergent resistant lipid raft fraction
- glutaminergic synapse
- presynaptic regions
- cell surface
- cellular membrane
- Nucleus
- tertiary granule membrane
- specific granule membrane
- myelin sheath
- microsomal membrane
- membrane rafts
- microvilli
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cd47 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cell-cell adhesion
- positive regulation of cell proliferation
- regulation of nitric oxide biosynthetic process
- regulation of Fc receptor mediated stimulatory signaling pathway
- regulation of interferon-gamma production
- positive regulation of monocyte extravasation
- integrin-mediated signaling pathway
- inflammatory response
- positive regulation of T cell activation
- angiogenesis
- apoptotic process
- cell migration
- positive regulation of inflammatory response
- regulation of tumor necrosis factor production
- positive regulation of stress fiber assembly
- cellular response to interleukin-1
- regulation of interleukin-6 production
- regulation of interleukin-10 production
- heterotypic cell-cell adhesion
- cellular response to interferon-gamma
- positive regulation of phagocytosis
- cellular response to interleukin-12
- regulation of interleukin-12 production
- negative regulation of phagocytosis
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- plasma membrane
- tertiary granule membrane
- cell surface
- specific granule membrane
Molecular Function
What the gene product does at the molecular level
- thrombospondin receptor activity
- protein binding
- protein binding involved in heterotypic cell-cell adhesion