Mms19 Gene Summary [Mouse]
Enables enzyme binding activity. Predicted to be involved in protein maturation. Predicted to be located in cytosol; nucleoplasm; and spindle. Predicted to be part of MMXD complex and cytosolic [4Fe-4S] assembly targeting complex. Is expressed in several structures, including apical ectodermal ridge; liver; nervous system; neural retina; and trunk somite. Orthologous to human MMS19 (MMS19 homolog, cytosolic iron-sulfur assembly component). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Mms19 |
| Official Name | MMS19 cytosolic iron-sulfur assembly component [Source:MGI Symbol;Acc:MGI:1919449] |
| Ensembl ID | ENSMUSG00000025159 |
| Bio databases IDs | |
| Aliases | MMS19 cytosolic iron-sulfur assembly component |
| Synonyms | 2410001K24Rik, 2610042O15Rik, C86341, CIAO4, hMMS19, MET18, MMS19 cytosolic iron-sulfur assembly component, MMS19 cytosolic iron-sulphur assembly component, MMS19 homolog, cytosolic iron-sulfur assembly component, MMS19 homolog, cytosolic iron-sulphur assembly component, MMS19L |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mms19 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- RNAPII transcription regulator C-terminal
- transcription co-activator
- C domain
- Dos2-interacting transcription regulator of RNA-Pol-II
- enzyme binding
- protein binding
- estrogen receptor binding
- a/b binding pocket
- estrogen receptor binding domain
- M17 aminopeptidase N-terminal domain 2
Pathways
Biological processes and signaling networks where the Mms19 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- spindle apparatus
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mms19 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- positive regulation of transcription, DNA-dependent
- chromosome segregation
Cellular Component
Where in the cell the gene product is active
- MMXD complex
- nucleus
- centrosome
- cytoplasm
- membrane
- spindle
- cytosol
- holo TFIIH complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription coactivator activity
- estrogen receptor binding
- protein binding, bridging
- receptor signaling complex scaffold activity
- enzyme binding